Author

D. Shepherd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

F. M. Platt· 2 shared N. Platt· 2 shared Y. Weng· 2 shared A. B. Brueggemann· 1 shared A. Galione· 1 shared A. J. van Tonder· 1 shared A. Kurioka· 1 shared B. Paul· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

F. M. Platt

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Author profile →

4 papers

Recent·Most cited

A large attachment organelle mediates interaction between a novel Nanobdellota archaeon YN1 and its host

M. D. Johnson, H. Sakai, B. Paul, T. Nunorura, S. Dalvi, M. Mudaliyar, D. Shepherd, M. Shimizu, S. Udupa, M. Ohkuma, N. Kurosawa, D. Ghosal

This study isolates and characterizes a novel Nanobdellota archaeon and its host, revealing an attachment organelle that mediates their ectosymbiotic interaction.

bioRxiv · May 4, 2024 · PreprintMicrobiology

Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome

N. Platt, D. Shepherd, Y. Weng, G. C. Churchill, A. Galione, F. M. Platt

This study shows that lysosomal Ca2+ release is essential for NLRP3 inflammasome priming and IL-1β production in mice with Niemann-Pick Type C or Tpcn1/Tpcn2 deficiency.

bioRxiv · Jan 6, 2022 · PreprintImmunology

Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple Mycobacterium lineages and non-tubercular mycobacteria.

F. M. Platt, Y. Weng, D. Shepherd, Y. Lu, N. Krishnan, B. Robertson, N. Platt, G. Larrouy-Maumus

This study investigates whether lipid extracts from various mycobacterial strains inhibit the NPC1 pathway, finding that inhibition occurs in most strains but not in Mycobacterium canettii.

bioRxiv · Sep 6, 2021 · PreprintMicrobiology

Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways

A. Kurioka, B. van Wilgenburg, R. R. Javan, R. Hoyle, A. J. van Tonder, C. L. Harrold, T. Leng, L. J. Howson, D. Shepherd, V. Cerundolo, A. B. Brueggemann, P. Klenerman

This study shows that diverse Streptococcus pneumoniae strains activate MAIT cells via MR1-dependent and cytokine-driven pathways, with conserved riboflavin operon genes across strains.

bioRxiv · Jul 17, 2017Immunology