D. Ghosal

Novel cell-to-cell interactions revealed by cryotomography of a DPANN coculture system

This study uses cryo-ET to reveal intercellular nanotubes between a DPANN archaeon and its host, providing insights into host-DPANN communication and proteomic changes during symbiosis.

A large attachment organelle mediates interaction between a novel Nanobdellota archaeon YN1 and its host

This study isolates and characterizes a novel Nanobdellota archaeon and its host, revealing an attachment organelle that mediates their ectosymbiotic interaction.

An obligate aerobe adapts to hypoxia by hybridising fermentation with carbon storage

This study reveals how Mycobacterium smegmatis adapts to hypoxia by combining fermentative hydrogen production with carbon storage through lipid droplets.

Structure and Function of the Dot/Icm T4SS

This study constructs a nearly-complete model of the Legionella pneumophila Dot/Icm T4SS using subtomogram averaging and integrative modeling, revealing structural insights into six new components and their functional interactions.

Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly

The paper presents a cryo-EM structure of the Agrobacterium tumefaciens T-pilus, revealing a 1:1 stoichiometric assembly of VirB2 and phosphatidylglycerol with unique electrostatic interactions and structural features.

Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealedby cryo-electron tomography

This study uses cryo-electron tomography to reveal structural changes in Coxiella burnetii during its biphasic developmental cycle, showing morphological transitions and T4BSS-associated structures.

A novel widespread bacterial structure related to the flagellar type III secretion system

The paper identifies a novel widespread bacterial structure related to the flagellar type III secretion system, suggesting its involvement in diverse cellular functions.

Structure of the bacterial cellulose ribbon and its assembly-guiding cytoskeleton by electron cryotomography

This study uses cryo-electron tomography to reveal the structure of bacterial cellulose ribbons and a novel cytoskeletal structure called the cortical belt in Gluconacetobacter species.

In vivo structure of the Legionella type II secretion system by electron cryotomography

The paper presents the first in situ structure of the Legionella T2SS using cryo-ET, revealing architectural similarities and differences with T4P and supporting the piston model for substrate extrusion.

Stable sub-complexes observed in situ suggest a modular assembly pathway of the bacterial flagellar motor

The paper observes stable sub-complexes in bacterial flagellar motors using cryo-tomography, suggesting a modular assembly pathway involving independent outer- and inner-membrane sub-complexes.

The structural complexity of the Gammaproteobacteria flagellar motor is related to the type of its torque-generating stators

The paper uses cryo-electron tomography to analyze flagellar motor structures in three Gammaproteobacteria species, finding a correlation between stator type and structural complexity.

In vivo structures of the Helicobacter pylori cag type IV secretion system

This study uses electron cryotomography to reveal the in vivo structure of the Helicobacter pylori cag T4SS, showing its architecture and proposed delivery mechanism.

Structure of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis

This study uses electron cryotomography to visualize the archaellar motor and cytoplasmic cone in Thermococcus kodakaraensis, revealing structural differences from bacterial type IV pilus.

Structure of the Legionella Dot/Icm type IV secretion system in situ by electron cryotomography

The paper reports the in situ structure of the Legionella Dot/Icm T4BSS using electron cryotomography, revealing structural similarities to T4ASSs and highlighting type-specific features.