Y. Weng

Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration

The paper identifies a splice variant-dependent localization of PMCA2 to lysosomes and links it to neurodegenerative diseases.

Glucosylceramide depletion disrupts endolysosomal function in GBA-linked Parkinsons fibroblasts?

This study shows that GlcCer depletion in GBA-PD fibroblasts disrupts endolysosomal function, with adaGlcCer reversing pH and volume changes.

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome

This study shows that lysosomal Ca2+ release is essential for NLRP3 inflammasome priming and IL-1β production in mice with Niemann-Pick Type C or Tpcn1/Tpcn2 deficiency.

Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple Mycobacterium lineages and non-tubercular mycobacteria.

This study investigates whether lipid extracts from various mycobacterial strains inhibit the NPC1 pathway, finding that inhibition occurs in most strains but not in Mycobacterium canettii.

Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate-degrading Enzymes

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.