Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274
S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell
The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.
bioRxiv · Oct 2, 2019Physiology