J. Cooper

Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes in a mass mortality event in wild seabirds and co-location with dead seals

The paper reports the co-circulation of H5N1 and H5N5 HPAIV subtypes in a mass mortality event involving seabirds and seals in Great Britain, with the first recorded instance of two subtypes co-occurring in the same avian population and the first H5N5 detection in mammals in GB.

Temporally resolved growth patterns reveal novel information about the polygenic nature of complex quantitative traits

This study uses high-temporal-resolution plant height data to show that genetic and environmental factors influence plant growth differently across the growing season.

Plant height defined growth curves during vegetative development have the potential to predict end of season maize yield and assist with mid-season management decisions

The paper uses UAV-derived plant height data to predict maize grain yield variation within fields, showing moderate predictive accuracy but limitations in drought-stressed environments.

Dissecting the temporal phenomics and genomics of maize canopy cover using UAV mediated image capture

This study uses UAV imagery to track maize canopy cover over time, revealing its genetic and environmental influences and the limitations of single-time-point phenotyping.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

How does perception of zoo animal welfare influence public attitudes, experiences, and behavioural intentions? A mixed-methods systematic review

This review identifies factors influencing public perceptions of zoo animal welfare and their effects on attitudes, experiences, and behaviors, recommending improvements for future research.

An RGB based deep neural network for high fidelity Fusarium head blight phenotyping in wheat

This paper introduces an RGB-based deep neural network for high-fidelity Fusarium head blight phenotyping in wheat, achieving accuracy comparable to human scoring and demonstrating strong generalizability across field conditions.

Cas phosphorylation regulates focal adhesion assembly

The paper shows that Cas phosphorylation and clustering with Crk/CrkL and inactive integrin β1 precede focal adhesion assembly, with Rac1 and ubiquitin proteasome system regulating this process.

Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section

The paper develops a multi-modal imaging platform combining H&E and high-plex immunofluorescence for colorectal cancer diagnosis, showing improved predictive models for progression-free survival.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

Models of the cardiac L-type calcium current: a quantitative review

This paper reviews 73 mammalian models of the cardiac L-type calcium current, finds large variability in their predictions, and provides model code and data sources.

Computational Modeling: Human Dynamic Model

This paper introduces a physics-based dynamic model of human movement with 48 degrees of freedom to analyze and simulate bipedal movements, supporting applications in biomechanics and virtual reality.

Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain developmen

The paper identifies Fbxo45 as a N-cadherin-binding protein that regulates neuron migration by interacting with SPRY motifs in the extracellular domain of N-cadherin.

Septin Roles and Mechanisms in Organization of Endothelial Cell Junctions

This study investigates the role of septin 2 in endothelial cell junction organization, showing its localization is critical for maintaining junctional integrity and that TNF-α disrupts this localization.

Detection of H3N8 influenza A virus with multiple mammalian-adaptive mutations in a rescued Grey seal (Halichoerus grypus) pup

The paper reports the detection of H3N8 influenza A virus in a Grey seal pup, identifies mammalian-adaptive mutations, and suggests potential zoonotic risk and pandemic surveillance relevance.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.