Author

P. Rodrigues

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. O'Connor· 2 shared D. White· 2 shared J. Hawksworth· 2 shared M. Aldrovandi· 2 shared R. Andrews· 2 shared S. Allen· 2 shared S. Meckelmann· 2 shared V. O'Donnell· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

A. O'Connor

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

M. Sciacovelli, A. Dugourd, L. Valcarcel Jimenez, M. Yang, E. Nikitopoulou, A. S. Costa, L. Tronci, V. Caraffini, P. Rodrigues, C. Schmidt, D. G. Ryan, T. Young, V. Zecchini, S. H. Rossi, C. Massie, , C. Frezza

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

M. Misheva, K. Kotzamanis, L. Davies, V. Tyrrell, P. Rodrigues, G. Benavides, H. Christine, R. Murphy, P. Kennedy, P. Taylor, M. Rosas, S. Jones, J. McLaren, S. Deshpande, R. Andrews, , V. O'Donnell

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

bioRxiv · Aug 17, 2020Biochemistry

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications

J. Alvarez-Jarreta, P. Rodrigues, E. Fahy, A. O'Connor, A. Price, C. Gaud, S. Andrews, P. Benton, G. Siuzdak, J. Hawksworth, M. Valdivia, S. Allen, V. O'Donnell

LipidFinder 2.0 improves lipidomics analysis with new modules for artefact filtering, isotope deletion, and FDR assessment, showing better performance than existing tools.

bioRxiv · Aug 16, 2020Biochemistry

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

bioRxiv · Oct 2, 2019Physiology