Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer
K. Chaudagar, H. M. Hieromnimon, R. Khurana…·A. Patnaik
The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.