Author

Y. Kfoury

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:cell-cell communication· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Approach:deep learning· 2

Frequent Co-Authors

D. T. Scadden· 4 shared N. Baryawno· 4 shared D. B. Sykes· 3 shared N. Severe· 3 shared S. Mei· 3 shared T. Hirz· 3 shared A. O. Subtelny· 2 shared C.-L. Wu· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

D. T. Scadden

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Myelodysplastic syndromes disable human CD271+VCAM1+CD146+ niches supporting normal hematopoietic stem/progenitor cells

Y. kawano, H. Kawano, D. Ghoneim, T. J. Fountaine, D. K. Byun, M. W. LaMere, J. H. Mendler, T.-C. Ho, N. A. Salama, J. R. Myers, S. E. Hussein, B. J. Frisch, J. M. Ashton, M. Azadniv, J. L. Liesveld, , L. M. Calvi

The paper identifies a specific MSC subset supporting normal HSPCs and shows its dysfunction in MDS.

bioRxiv · Apr 9, 2023 · PreprintCancer Biology

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

A. M. Alchahin, S. Mei, I. Tsea, T. Hirz, Y. Kfoury, D. Dahl, C.-L. Wu, A. O. Subtelny, S. Wu, D. T. Scadden, J. H. Shin, P. J. Saylor, D. B. Sykes, P. V. Kharchenko, N. Baryawno

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

bioRxiv · Jun 28, 2022Cancer Biology

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

T. Hirz, S. Mei, H. Sarkar, Y. Kfoury, S. Wu, B. M. Verhoeven, A. O. Subtelny, D. V. Zlatev, M. W. Wszolek, K. Salari, E. Murray, F. Chen, E. Z. Macosko, C.-L. Wu, D. T. Scadden, , D. B. Sykes

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

N. Baryawno, Y. Kfoury, N. Severe, S. Mei, K. U. Gustafsson, T. Hirz, T. Brouse, E. Scadden, B. Choi, N. Barkas, J. Shin, P. Saylor, D. Scadden, D. Sykes, P. Kharchenko

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

bioRxiv · Feb 21, 2019 · PreprintCell Biology