Author

N. Severe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell-cell communication· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

D. Scadden· 3 shared N. Baryawno· 3 shared Y. Kfoury· 3 shared K. D. Kokkaliaris· 2 shared K. Gustafsson· 2 shared N. Barkas· 2 shared T. Brouse· 2 shared A. Anselmo· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

D. Scadden

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

Y. Kfoury, F. Ji, M. Mazzola, D. B. Sykes, A. K. Scherer, A. Anselmo, Y. Akiyama, F. Mercier, N. Severe, K. D. Kokkaliaris, T. Brouse, J. Seidl, A. Papzian, P. Ivanov, M. K. Mansour, , D. T. Scadden

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

bioRxiv · Apr 13, 2021Cell Biology

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

N. Baryawno, Y. Kfoury, N. Severe, S. Mei, K. U. Gustafsson, T. Hirz, T. Brouse, E. Scadden, B. Choi, N. Barkas, J. Shin, P. Saylor, D. Scadden, D. Sykes, P. Kharchenko

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

bioRxiv · Feb 21, 2019 · PreprintCell Biology