Loss of epigenetic regulation disrupts lineage integrity, reactivatesmultipotency and promotes breast cancer
E. Langille, K. N. Al-Zahrani, Z. Ma, A. Malik, S. K. Loganathan, D. Trcka, J. Liu, K. Kozma, R. Tsai, K. Teng, R. Espin, S. Barutcu, T. Nguyen, R. Bremner, H. W. Jackson, , D. Schramek
This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.
bioRxiv · Oct 22, 2021 · PreprintCancer Biology