K. Chan

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Social stress induces autoimmune responses against the brain to promote stress susceptibility

This study links social stress to autoimmune responses against the brain, showing increased IgG antibodies correlate with depression-like behaviors in mice and humans.

Prioritizing Management for Cumulative Impacts

This paper identifies leverage nodes in an impact network to prioritize environmental management for reducing risks to ecosystems and species.

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

Treating Porcine Abscesses With Histotripsy: A Pilot Study

This study evaluates histotripsy for treating abscesses in pigs, finding cavitation histotripsy more effective at reducing bacterial load with less treatment volume.

Comparison of SARS-CoV-2 Indirect and Direct Detection Methods

This paper compares indirect and direct SARS-CoV-2 detection methods, finding that BGI's system is most sensitive but costly, while direct methods are less sensitive but faster and cheaper.

Molecular mechanism of mitochondrial phosphatidate transfer by Ups1/Mdm35

This study investigates the molecular mechanism of PA transfer by Ups1/Mdm35 using crystal structures, molecular dynamics simulations, and biophysical assays, revealing conformational changes and regulatory factors.

Mapping Cumulative Impacts to Coastal Ecosystem Services in British Columbia

The paper maps cumulative impacts on 8 ecosystem services in coastal British Columbia using InVEST models, spatial data, and expert input, finding that access and quality impacts are more severe and diverse than supply impacts.

Maternal obesity alters uterine NK cell activity through a functional KIR2DL1/S1 imbalance

This study shows maternal obesity alters uterine NK cell activity by disrupting KIR2DL1/S1 balance and affecting angiokine/cytokine production and HLA-C2 responses.