Author

W. C. Wimley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. B. Pasquale· 2 shared K. Hristova· 2 shared S. Guha· 2 shared A. Soldano· 1 shared B. J. Nelson· 1 shared C. Chen· 1 shared C. G. Starr· 1 shared C. H. Chen· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

E. B. Pasquale

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Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivDec 1, 2022

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.

J. Ghimire, R. J. Hart, A. Soldano…·W. C. Wimley

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

DOI 10.1021/acsinfecdis.2c00640

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiophysicsbioRxivPreprintJun 7, 2022

The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size

E. Zapata-Mercado, G. Biener, D. McKenzie…·K. Hristova

This study investigates the relationship between EphA2 oligomer size and signaling efficacy, finding a correlation between mean oligomer size and tyrosine phosphorylation.

DOI 10.1101/2022.06.07.495003

experimental assaycell signaling & trafficking

𝕏 PostBluesky

BiophysicsbioRxivPreprintJun 6, 2022

Plasticity of transmembrane helix interactions in EphA2 dimers and oligomers

D. Wirth, E. Ozdemir, W. C. Wimley…·K. Hristova

The paper investigates how EphA2 transmembrane helix mutations affect receptor-receptor interactions using FRET and FIF, finding plasticity in dimer interfaces rather than a binary switch between active/inactive states.

DOI 10.1101/2022.06.06.495010

experimental assaycell signaling & trafficking

𝕏 PostBluesky

BiochemistrybioRxivNov 1, 2020

Rational tuning of a membrane-perforating antimicrobial peptide to selectively target membranes of different lipid composition

C. H. Chen, C. G. Starr, S. Guha…·J. Ulmschneider

This paper tunes an antimicrobial peptide to selectively target membranes of different lipid compositions using high-throughput screening and molecular dynamics simulations.

DOI 10.1007/s00232-021-00174-1

deep learningstatistical model

𝕏 PostBluesky