Lysosomal signaling pathways influence heart rhythm, and regulate atrial function
E. Akerman, R. A. Capel, E. Rog-Zielinska, A. Winbo, D. Aston, F. Falter, R. B. A. Mu-u-min, M. J. Read, S. J. Bose, P. Swietach, J. Wang, A. D. Corbett, A. Koschinski, S. Calamaio, D. Melgari, , R. A. B. Burton
This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.
bioRxiv · Jun 10, 2024Physiology