A. Dev

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

Surface adhesion and membrane fluctuations influence the elastic modulus of extracellular vesicles

This study develops a method to accurately measure the elastic modulus of extracellular vesicles, showing that surface adhesion and membrane fluctuations significantly affect the results.

Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery

This study shows that mesenchymal stem cells (MSCs) reduce inflammation in a mouse model of Crohn's disease by modulating T cells and macrophages in the mesentery, with long-term effects through macrophage reprogramming.

Analyses of single extracellular vesicles from non-small lung cancer cells to reveal effects by Epidermal growth factor inhibitor treatments

This paper uses single extracellular vesicle analysis to show that osimertinib treatment increases PD-L1, EGFR, and HER2 positive EVs in EGFR-mutant NSCLC cells, while erlotinib does not, suggesting EVs as potential biomarkers for treatment response.

Design and optimization of silicon-based electrokinetic microchip for sensitive detection of small extracellular vesicles

This paper designs and optimizes a silicon-based electrokinetic microchip for sensitive detection of small extracellular vesicles, achieving a low limit of detection.

Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients

This study develops an electrokinetic sensor to detect surface proteins on extracellular vesicles from NSCLC patients' liquid biopsies, showing interpatient differences and treatment response changes.

Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features

This study uses combined atomic force and fluorescence microscopy to analyze molecular and biophysical features of single extracellular vesicles from different cell lines, revealing correlations and heterogeneity in their properties.

High throughput imaging of nanoscale extracellular vesicles by scanning electron microscopy for accurate size-based profiling and morphological analysis.

This study uses scanning electron microscopy to profile nanoscale extracellular vesicles, showing better performance than nanoparticle tracking analysis for smaller vesicles and artifact identification.