D. Patel

Effects of nano urea on growth and gene expression of Arabidopsis thaliana in hydroponics

This study shows that nano urea enhances biomass and chlorophyll content in Arabidopsis thaliana hydroponics compared to bulk urea, with differential gene expression patterns.

Antiviral insulin signaling during West Nile virus infection results in viral mutations

This study shows that activating insulin signaling in mosquitoes during West Nile virus infection leads to viral mutations that may help the virus escape antiviral pressure.

Subcellular visualization of the distribution of atmospheric dinitrogen fixed by Gluconacetobacter diazotrophicus bacteria in maize

The paper uses NanoSIMS imaging to visualize subcellular distribution of fixed nitrogen in maize inoculated with Gluconacetobacter diazotrophicus, showing nitrogen incorporation into chloroplasts.

Light-induced Extracellular Vesicle Adsorption

This paper introduces LEVA, a label-free, high-resolution, tunable platform for EV adsorption and characterization, demonstrating its versatility with various EV sources and applications.

Effect of Emoji on Autonomic Nervous System: Evidence from EDA and RSA studies

This study examines how emojis affect autonomic responses, finding increased sympathetic activity and decreased parasympathetic activity in both males and females during an emotional task.

Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions

This study shows Rab35 is essential for embryonic development and kidney/ureter homeostasis by regulating epithelial cell junctions, leading to hydronephrosis in mice.

Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes

The paper investigates how inhibiting chromatin modifier enzymes in cancer cells leads to cell-type-specific derepression of transposable elements, enhancing immune response through distinct mechanisms.

Identifying novel links between cardiovascular disease and insomnia by Drosophila modeling of genes from a pleiotropic GWAS locus

This study uses Drosophila models to investigate the role of genes from a GWAS locus in linking cardiovascular disease and insomnia, finding tissue-specific and cross-tissue effects on sleep and cardiac function.

Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication

The paper shows ethanol exposure in yeast increases Hsp90-dependent gene copy numbers, linking proteotoxic stress to domestication traits in beer and bread production.

Dynamic Bayesian modeling of the social behavior of Drosophila melanogaster

The paper models Drosophila melanogaster social behavior using Dynamic Bayesian Networks to predict pair behavior with high accuracy.

Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

This study shows brain-localized CD4 and CD8 T cells move via correlated random walks, not Levy walks, challenging previous claims of unique movement strategies in the brain.

Phenotypic, genomic, and transcriptomic heterogeneity in a pancreatic cancer cell line

The paper characterizes phenotypic, genomic, and transcriptomic heterogeneity in MIA PaCa-2 pancreatic cancer cell clones, showing distinct traits and suggesting its use as a model for studying cancer heterogeneity.

An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease

This study identifies a distinct pattern of skeletal muscle dysfunction in a mouse model of long-term post-viral lung disease caused by Sendai virus, showing reduced myofiber size without changes in myofiber type or protein synthesis/degradation markers.

Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations

This study uses cfMeDIP-seq to analyze cell-free methylomes in SCLC patients, identifying prognostic methylome clusters associated with biological pathways and repeat elements.

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

Variation of the Rdr1 gene insertion in wild populations of Nicotiana benthamiana (Solanaceae) and insights into recent species divergence

The paper uses genome-wide SNPs and multispecies coalescent methods to show that Nicotiana benthamiana is actually five distinct species, with LAB being one that split earlier from a common ancestor.

Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum

The paper investigates drought tolerance in sorghum by analyzing metabolomic, physiological, and transcriptomic responses to post-flowering drought in two genotypes.

Paralog editing tunes rice stomatal density to maintain photosynthesis and improve drought tolerance

The paper edits paralogs of STOMAGEN in rice to reduce stomatal density, improving drought tolerance without compromising photosynthesis.

Heterozygous transcriptional signatures unmask variable premature termination codon (PTC) burden alongside pathway-specific adaptations in blood outgrowth endothelial cells from patients with nonsense DNA variants causing hereditary hemorrhagic telangiectasia

The paper examines the effects of nonsense DNA variants in HHT patients by analyzing transcriptional signatures and PTC burden in BOECs, finding pathway-independent changes in protein modification and stress-related patterns.

Ankylosis homologue mediates cellular efflux of ATP, not pyrophosphate

The paper shows ANKH mediates ATP release, not PPi, and both ANKH and ABCC6 contribute to plasma PPi by extruding NTPs, not PPi directly.

Structure-function Specialisation of the Interfascicular Matrix in the Human Achilles Tendon

This study shows the human Achilles tendon's interfascicular matrix is specialised for energy storage with increased elasticity and fatigue resistance, which diminish with age due to proteome changes.

High Light and High Temperature Reduce Photosynthesis via Different Mechanisms in the C4 Model Setaria viridis

This study examines how high light and high temperature affect photosynthesis in Setaria viridis, revealing distinct mechanisms and acclimation strategies in C4 plants.

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

The paper identifies Givinostat as a direct inhibitor of CGGBP1-DNA interaction, expanding its known mechanism beyond HDAC inhibition.

Implementing and assessing an alchemical method for calculating protein-protein binding free energy

The paper implements an alchemical method to calculate protein-protein binding free energy changes due to mutations and assesses its accuracy on small and large complexes.

Converting Microwave Ovens into Plasma-Generating Decontamination Units for N-95 Respirators

The paper demonstrates a method to decontaminate N-95 respirators using a modified microwave oven, achieving significant viral and bacterial reduction without damaging the respirators.

Short-wavelength-sensitive 2 (Sws2) visual photopigment models combined with atomistic molecular simulations to predict spectral peaks of absorbance

This study uses homology modeling and molecular dynamics simulations to predict the spectral peak of absorbance (λmax) for Sws2 cone photopigments with high accuracy.

Does plant root architecture respond to potassium nutrition under water stress? A case from rice seedling root responses.

This study investigates how potassium nutrition affects rice seedling root architecture under water stress and finds that K availability influences root morphology but not necessarily growth under severe stress.

Linkage mapping and QTL analysis of flowering time using ddRAD sequencing with genotype error correction in Brassica napus

This study uses ddRAD sequencing with genotype error correction to map flowering time QTLs in Brassica napus, identifying a QTL on chromosome C2 near flowering time genes.