K. L. Mack

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

Evolution of spatial and temporal cis-regulatory divergence between marine and freshwater sticklebacks

This study identifies cis-regulatory divergence between marine and freshwater sticklebacks using allele-specific expression in hybrids, showing widespread regulatory changes and lineage-specific selection.

Environmentally robust cis-regulatory changes underlie rapid climatic adaptation

This study identifies cis-regulatory divergence as a major driver of adaptive gene expression changes in house mice across thermal environments, with trans-effects contributing to plasticity.

Convergent patterns of gene expression and protein evolution associated with adaptation to desert environments in rodents

The paper identifies convergent gene expression patterns in desert-adapted rodents, showing 8.6% of genes exhibit expression evolution convergence, suggesting gene regulation plays a key role in desert adaptation.

Tuning Hsp104 specificity to selectively detoxify alpha-synuclein

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

Plasticity in gene expression facilitates invasion of the desert environment in house mice

The paper examines how gene expression plasticity aids house mice in adapting to desert environments, finding that desert mice show reduced plasticity under stress while non-desert mice shift towards desert-like expression.

Repeated evolution of circadian clock dysregulation in cavefish populations

This study shows that cavefish populations have independently evolved circadian clock dysregulation, with reduced transcriptome rhythmicity and sleep reduction linked to specific gene mutations.