BioengineeringbioRxiv
Tuning Hsp104 specificity to selectively detoxify alpha-synuclein
K. L. Mack, H. Kim, M. E. Jackrel…·J. Shorter
The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.
DOI 10.1016/j.molcel.2023.07.029