Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.
L. Borriello, A. Coste, V. Sharma, G. Karagiannis, Y. Lin, Y. Wang, X. Ye, C. Duran, X. Chen, E. Dalla, D. Singh, M. Oktay, J. Condeelis, D. Entenberg
This study identifies how primary tumor-associated macrophages prime disseminating tumor cells for invasion and dormancy, revealing a critical post-extravasation step in metastasis.
bioRxiv · Feb 4, 2021Cancer Biology