D. Entenberg

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

FAK family proteins regulate in vivo breast cancer metastasis via distinct mechanisms.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.

Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections

This study shows macrophages promote tumor cell extravasation via thin membranous connections (TMCs) in vitro and in vivo, and reducing TMC formation decreases metastasis.

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

This study identifies a mechanism by which macrophages induce MenaINV expression in breast cancer cells through cooperative NF-κB and Notch1 signaling, leading to increased metastasis.

Spatiotemporal coordination of stem cell behavior following alveolar injury

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

Interleukin 4 controls the role of macrophages in pulmonary metastatic tumor cell seeding and growth

This study shows that IL4 signaling in macrophages promotes lung metastasis by enhancing tumor cell extravasation and regulating pro-tumoral gene expression.

Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

This study identifies how primary tumor-associated macrophages prime disseminating tumor cells for invasion and dormancy, revealing a critical post-extravasation step in metastasis.

SUN-MKL1 crosstalk regulates nuclear deformation and fast motility of breast carcinoma cells in fibrillar ECM micro-environment

Live imaging of breast tumors shows macrophage-dependent induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.