Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
N. A. Traphagen, G. N. Schwartz, S. Tau, A. Jiang, S. R. Hosford, A. E. Goen, A. M. Roberts, B. A. Romo, A. L. Johnson, E.-C. K. Duffy, E. Demidenko, P. Heverly, Y. Mosesson, S. M. Soucy, F. Kolling, T. W. Miller
This study shows estrogen therapy induces DNA damage in ER+ breast cancer cells, which can be enhanced by PARP inhibition to improve treatment outcomes.
bioRxiv · Mar 16, 2023Cancer Biology