Author

E. Dray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Ashworth· 1 shared A. Gulati· 1 shared A. Hsu· 1 shared A. J. Cesare· 1 shared A. Johns· 1 shared A. K. Gupta· 1 shared A. K. Verma· 1 shared A. Olazabal Herrero· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Ashworth

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

P. C. Boddu, A. K. Gupta, R. Roy, B. De La Pena Avalos, A. Olazabal Herrero, N. Neuenkirchen, J. T. Zimmer, N. S. Chandhok, D. King, Y. Nannya, S. Ogawa, H. Lin, M. D. Simon, E. Dray, G. Kupfer, , M. M. Pillai

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

bioRxiv · Feb 25, 2023Cancer Biology

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology

Targeting DNA damage response and Replication Stress in Pancreatic Cancer

S. Dreyer, R. Upstill-Goddard, V. Paulus-Hock, C. Paris, E. Maria-Lampraki, E. Dray, B. Serrels, S. Rebus, H. Brunton, C. Nourse, U.-M. Bailey, M. Jones, K. Moran-Jones, D. Wright, F. Duthie, , Lord

The paper identifies novel therapeutic strategies for pancreatic cancer by analyzing DNA damage response and replication stress in patient-derived cell lines.

bioRxiv · Jul 24, 2019Cancer Biology

The chromatin remodeler SMARCD3 regulates cell cycle progression and its expression predicts survival outcome in ER+ breast cancer

R. Tropee, B. L. de la Pena Avalos, M. Gough, C. Snell, P. H. G. Duijf, E. Dray

This paper shows SMARCD3 expression correlates with survival in ER+ breast cancer and regulates cell cycle progression, suggesting it as a prognostic biomarker and tumor suppressor.

bioRxiv · Jul 2, 2019 · PreprintCancer Biology