Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model
H. Monzo, M. Hyytiäinen, E. Elbasani, K. Kalander, J. Wall, L. Moyano-Galceran, J. Tanjore Ramanathan, J. Jukonen, P. Laakkonen, A. Ristimäki, J. Carlson, K. Lehti, S. Salehi, P. Puolakkainen, C. Haglund, , P. M. Ojala
This study evaluates anti-SSEA-4 CAR-T cells in ovarian cancer models, showing efficacy against SSEA-4 positive cells but highlighting dose-dependent toxicity.
bioRxiv · Sep 2, 2022Cancer Biology