Author

P. Laakkonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

V. Le Joncour· 4 shared J. Merisaari· 2 shared J. Tanjore Ramanathan· 2 shared J. Westermarck· 2 shared P. M. Ojala· 2 shared A. Ristimäki· 1 shared C. Haglund· 1 shared D. B. Kastrinsky· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCancer Biology

V. Le Joncour

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model

H. Monzo, M. Hyytiäinen, E. Elbasani, K. Kalander, J. Wall, L. Moyano-Galceran, J. Tanjore Ramanathan, J. Jukonen, P. Laakkonen, A. Ristimäki, J. Carlson, K. Lehti, S. Salehi, P. Puolakkainen, C. Haglund, , P. M. Ojala

This study evaluates anti-SSEA-4 CAR-T cells in ovarian cancer models, showing efficacy against SSEA-4 positive cells but highlighting dose-dependent toxicity.

bioRxiv · Sep 2, 2022Cancer Biology

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposis sarcoma studies

K. Tuohinto, T. A. DiMaio, E. A. Kiss, P. Laakkonen, P. Saharinen, T. Karnezis, M. Lagunoff, P. M. Ojala

This study identifies KSHV-infected lymphatic endothelial colony forming cells as a novel model for studying Kaposis sarcoma, showing their ability to persist in vivo and recapitulate tumor characteristics.

bioRxiv · Jul 25, 2022Microbiology

Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model

S. Samanta, V. Le Joncour, O. Wegrzyniak, V. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen

This study develops heparin-derived nanoprobes that cross the blood-brain barrier and target glioma in mice, showing effective imaging and therapeutic potential.

bioRxiv · Jan 7, 2022Bioengineering

Circumventing drug treatment? Polyethylenimine functionalized nanoparticles inherently and selectively kill patient-derived glioblastoma stem cells

N. Prabhakar, J. Merisaari, V. Le Joncour, M. Peurla, D. Sen Karaman, E. Casals, P. Laakkonen, J. Westermarck, J. Rosenholm

This study shows that PEI-functionalized nanoparticles selectively kill glioblastoma stem cells by lysosomal membrane rupture without affecting other cancer cells.

bioRxiv · Dec 14, 2020 · PreprintCancer Biology

Prostate Specific Membrane Antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to brain

J. Tanjore Ramanathan, S. Lehtipuro, H. Sihto, J. Tovari, L. Reiniger, V. Teglasi, J. Moldvay, M. Nykter, H. Haapasalo, V. Le Joncour, P. Laakkonen

The paper links PSMA vascular expression in primary lung carcinomas to faster brain metastasis and poorer survival.

bioRxiv · Dec 8, 2019Pathology

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma

J. Merisaari, O. V. Denisova, M. Doroszko, V. Le Joncour, P. Johansson, W. P. J. Leenders, D. B. Kastrinsky, Z. Nilesh, G. Narla, P. Laakkonen, S. Nelander, M. Ohlmeyer, J. Westermarck

This study shows that BBB-permeable PP2A activators reduce GB tumor growth and improve survival in mice with diverse GB subtypes.

bioRxiv · Sep 27, 2019 · PreprintCancer Biology