M. Francois

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

Heterogeneity in collective endothelial cell behavior is a driver of arterio-venous remodeling

The paper identifies heterogeneous collective endothelial cell behaviors driving arterio-venous remodeling during vascular development in zebrafish.

Oncogenic herpesvirus engages the endothelial transcription factors SOX18 and PROX1 to increase viral genome copies and virus production

This study shows that SOX18 and PROX1, endothelial transcription factors, regulate KSHV lytic replication and virus production in lymphatic endothelial cells.

Early origin and deep conservation of enhancers in animals

The paper shows enhancer activity is conserved across 700 million years of trans-phyletic divergence.

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.