Author

E. Esakov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

O. Reizes· 6 shared J. Lathia· 4 shared C. Braley· 3 shared C. M. Michener· 2 shared G. Dey· 2 shared M. P. Horowitz· 2 shared P. G. Rose· 2 shared R. Bharti· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersCancer Biology

O. Reizes

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Author profile →

6 papers

Recent·Most cited

Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell Penetrating Peptides in Triple Negative Breast Cancers

E. E. Mulkearns-Hubert, E. Esakov, S. Ben-Salem, R. Bharti, N. Hajdari, S. Johnson, A. Myers, I. N. Smith, S. Bandyopadhyay, C. Eng, E. Downs-Kelly, J. Lathia, O. Reizes

This study demonstrates that a cell-penetrating peptide targeting the Cx26/NANOG/FAK complex inhibits tumor growth and alters NANOG activity in triple-negative breast cancer.

bioRxiv · Sep 9, 2021 · PreprintCancer Biology

A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Z. Alali, M. P. Horowitz, D. Chau, L. Trestan, J. Hao, P. Qi, E. Esakov, R. L. DeBernardo, J. S. Yu, O. Reizes

This paper introduces a novel non-invasive mouse model of HIPEC to study its efficacy in epithelial ovarian cancer.

bioRxiv · May 16, 2021 · PreprintCancer Biology

LCK Regulates Homologous Recombination DNA Repair Identifying a New Therapeutic Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer

G. Dey, R. Bharti, C. Braley, R. Alluri, E. Esakov, K. Crean-Tate, K. McCrae, A. Joehlin-Price, P. G. Rose, J. Lathia, Z. Gong, O. Reizes

This study identifies LCK's role in HR repair in ovarian cancer, showing its inhibition sensitizes HR-proficient tumors to PARP inhibitors.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology

Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses

M. P. Horowitz, Z. Alali, T. Alban, C. Hong, E. Esakov, T. H. Hwang, J. Lathia, C. M. Michener, R. DeBernardo, O. Reizes

This study uses single-cell RNA-seq to analyze tumor responses to HIPEC in ovarian cancer patients, identifying distinct cellular and molecular changes.

bioRxiv · Oct 5, 2020 · PreprintCancer Biology

Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors

K. K. Crean-Tate, C. Braley, G. Dey, E. Esakov, C. Saygin, A. Trestan, D. J. Silver, S. M. Turaga, E. V. Connor, R. Debernardo, C. M. Michener, P. G. Rose, J. Lathia, O. Reizes

This study shows that pretreatment with LCK inhibitors makes cisplatin-resistant endometrioid ovarian tumors more sensitive to cisplatin, improving cell viability and tumor growth inhibition.

bioRxiv · Jun 18, 2020Cancer Biology

Use of Transabdominal Ultrasound for the Detection of Intra-Peritoneal Tumor Engraftment and Growth in Mouse Xenografts of Epithelial Ovarian Cancer

L. Chambers, E. Esakov, C. Braley, M. AlHilli, C. Michener, O. Reizes

This study evaluates transabdominal ultrasound (TAUS) for detecting intra-peritoneal tumor growth in mouse xenografts of epithelial ovarian cancer, showing it can detect tumors as small as 2 mm and as early as seven days post-injection.

bioRxiv · Jan 20, 2020Cancer Biology