Author

E. F. Castillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. G. In· 4 shared A. S. Romero· 2 shared M. J. Campen· 2 shared R. Atanga· 2 shared S. D. Merkley· 2 shared A. Benavidez· 1 shared A. Brearley· 1 shared A. J. Hernandez· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

J. G. In

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Uranium-bearing dust induces differentiation and expansion of enteroendocrine cells in human colonoids

R. Atanga, L. L. Appell, F. T. Lauer, A. Brearley, M. J. Campen, E. F. Castillo, J. G. In

This study shows uranium-bearing dust exposure induces differentiation and expansion of enteroendocrine cells in human colonoids through non-canonical pathways.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Inflammatory macrophages prevent colonic goblet and enteroendocrine cell differentiation through Notch signaling

R. Atanga, A. S. Romero, A. J. Hernandez, E. Peralta-Herrera, S. Merkley, J. G. In, E. F. Castillo

The paper shows that inflammatory macrophages inhibit goblet and enteroendocrine cell differentiation in the gut via Notch signaling.

bioRxiv · Jun 29, 2023 · PreprintImmunology

In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure

M. M. Garcia, A. S. Romero, S. D. Merkley, J. L. Meyer-Hagen, C. Forbes, E. El Hayek, D. P. Sciezka, R. Templeton, J. Gonzalez-Estrella, Y. Jin, H. Gu, A. Benavidez, R. P. Hunter, S. Lucas, G. Herbert, , E. F. Castillo

This study shows that ingested microplastics can cross the gut barrier, enter systemic circulation, accumulate in tissues, and alter metabolomic profiles in mice.

bioRxiv · Jun 2, 2023 · PreprintPharmacology & Toxicology

G-Trap Assay I: Small GTPases as sensitive immune response biomarkers for active bacteremia

R. Clark, V. Bondu, P. C. Simons, L. Shevy, E. F. Castillo, S. Young, N. Kanagy, A. Wandinger-Ness, T. Howdieshell, T. Buranda

This study uses a novel G-Trap assay to detect GTPase activation in trauma patients, showing it correlates with infection-induced immune activation and antibiotic treatment effects.

bioRxiv · Jun 9, 2022 · PreprintImmunology

Non-autophagy role of Atg5 and NBR1 in unconventional secretion of IL-12 prevents gut dysbiosis and inflammation

E. F. Castillo, S. D. Merkley, S. M. Goodfellow, Y. Guo, Z. E. R. Wilton, J. R. Byrum, K. C. Schwalm, D. L. Dinwiddie, R. R. Gullapalli, V. P. Deretic, A. Jimenez Hernandez, S. B. Bradfute, J. G. In

This study shows that Atg5 in intestinal myeloid cells limits IL-12 secretion, preventing dysbiosis and inflammation by reducing IFN-gamma production.

bioRxiv · Dec 7, 2020Immunology