H. Gu

Role of Staphylococcus aureus Buoyant Density in the Development of Biofilm Associated Antibiotic Resistance

This study shows that Staphylococcus aureus cells with lower buoyant density resist antibiotics more and form biofilms at air-liquid interfaces, while higher buoyant density cells are more antibiotic-sensitive and form biofilms on liquid-solid interfaces.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

NEUROMETABOLOMIC IMPACTS OF MODELED WILDFIRE SMOKE AND PROTECTIVE BENEFITS OF ANTI-AGING THERAPEUTICS IN AGED FEMALE C57BL/6J MICE

This study examines the neurometabolomic effects of wood smoke exposure in aged mice and evaluates the protective effects of anti-aging therapies.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Single cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a pro-inflammatory metabolic signature in male mice at late adulthood

This study shows that neonatal BDE-99 exposure leads to persistent pro-inflammatory and metabolic dysregulation in the liver of male mice at late adulthood, linked to gut microbiome changes.

In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure

This study shows that ingested microplastics can cross the gut barrier, enter systemic circulation, accumulate in tissues, and alter metabolomic profiles in mice.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

Redefinition of archetypal phytoplankton-associated bacteria taxa based on globally distributed dinoflagellates and diatoms

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

High frequency soil polarization can phenotype crop roots noninvasively

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

Boreal Forest Height Mapping using Sentinel-1 Time Series and improved LSTM model

This paper develops an improved LSTM model for predicting boreal forest height using Sentinel-1 time series, achieving better accuracy than existing methods.

Ischemic stroke and dietary vitamin B12 deficiency in old-aged females impaired motor function, increased ischemic damage size, and changed metabolite profiles in brain and cecum tissue

This study shows that vitamin B12 deficiency in aged female mice worsens stroke outcomes by increasing brain damage and impairing motor function through apoptosis and mitochondrial metabolic changes.

Balanced chromosomal rearrangements offer insights into coding and noncoding genomic features associated with developmental disorders

The paper analyzes balanced chromosomal rearrangements in developmental disorders, finding noncoding variants disrupt TADs and contribute to pathogenic long-range positional effects.

Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota

This study shows that bile acid TCA promotes Candida albicans colonization and dissemination from the gut by altering host immunity and microbiota.

Combined free energy calculation and machine learning methods for understanding ligand unbinding kinetics

This paper develops a computational method combining free energy calculations and machine learning to predict ligand unbinding kinetics and identify key interactions for drug design.

Using hypertemporal Sentinel-1 data to predict forest growing stock volume

This study uses Sentinel-1 SAR data to predict forest growing stock volume, showing improved accuracy with more images and specific seasonal image combinations.

A warmer growing season triggers earlier following spring phenology

The paper shows warmer temperatures during the previous growing season advance spring phenology in the Northern Hemisphere, with a decline in this effect over time.

RPnet: A Reverse Projection Based Neural Network for Coarse-graining Metastable Conformational States for Protein Dynamics

This paper introduces RPnet, a neural network method for coarse-graining metastable conformational states in protein dynamics, showing comparable or better results than existing methods.

An Efficient Method to Quantify Structural Distributions in Heterogeneous cryo-EM Datasets

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

A bacterial "shield and sword": A previously uncharacterized two-component system protects uropathogenic Escherichia coli from host-derived oxidative insults and promotes hemolysin-mediated host cell pyroptosis

This study identifies a two-component system in UPEC that enhances bacterial survival under oxidative stress and promotes host cell pyroptosis via hemolysin.

Identification of biomarkers and candidate regulators for multiple myeloma under the knockout of AURKA

This study identifies biomarkers and candidate regulators in multiple myeloma under AURKA knockout using bioinformatics analysis of gene expression data.

Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

The potential function of forehead gland secretions in conflict resolution of the male Great Himalayan leaf-nosed bats

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

When and why an essential popular mineral-calcium-is an effective antifungal adjuvant against the human pathogen?

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

Soluble corn fiber reduces ovalbumin-induced sinonasal inflammation via the gut microbiota-airway axis

This study shows soluble corn fiber reduces ovalbumin-induced sinonasal inflammation in mice, but this effect is lost in mice on a western diet due to microbiota changes.

NAD+ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

This study shows that NAD+ redox imbalance worsens diabetic cardiomyopathy by impairing cardiomyocyte function and suggests NAMPT as a therapeutic target.

A Highly Sensitive Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue

This paper develops a fluorogenic assay to detect oxidative stress in live cells and renal tissue, showing improved sensitivity for identifying early signs of nephrotoxicity.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

Multivariate Analyses of Codon Usage of SARS-CoV-2 and other betacoronaviruses

This study analyzes codon usage patterns of SARS-CoV-2 and betacoronaviruses using multivariate methods, finding similar amino acid usage to bat and human SARSr-CoVs but distinct synonymous codon usage in spike and membrane genes.

Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.