A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response
K. A. Connolly, M. Kuchroo, A. Venkat, A. Khatun, J. Wang, I. William, N. Hornick, B. Fitzgerald, M. Damo, M. Y. Kasmani, C. Cui, E. Fagerberg, I. Monroy, A. Hutchins, J. F. Cheung, , N. S. Joshi
The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.
bioRxiv · Jan 27, 2021Immunology