The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin
M. Damo, C. Cui, I. William, N. I. Hornick, D. Kwok, K. Clulo, W. E. Damsky, J. S. Leventhal, N. S. Joshi
The paper shows that PD-1+ CD8 T cells in healthy skin remain tolerant to self-antigens and prevent tissue damage through PD-L1 upregulation on myeloid cells.
bioRxiv · Jul 9, 2021 · PreprintImmunology