Author

A. Tobin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Bhattarai· 1 shared A. Christopoulos· 1 shared A. G. Jamieson· 1 shared A. Glukhova· 1 shared A. Mahindra· 1 shared A. P. Waters· 1 shared A. Sanchez-Azqueta· 1 shared C. Doerig· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Bhattarai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology

Sampling of Structure and Sequence Space of Small Protein Folds

T. W. Linsky, K. Noble, A. Tobin, R. Crow, L. P. Carter, J. L. Urbauer, D. Baker, E.-M. Strauch

The paper designs and evaluates 30,000 de novo proteins to explore shape diversity, identifies 6,200 stable proteins, and develops a classifier for stability prediction.

bioRxiv · Mar 10, 2021Bioengineering

Validation of the protein kinase PfCLK3 as a multi-stage cross species malarial drug target

M. Alam, A. Sanchez-Azqueta, O. Janha, E. Flannery, A. Mahindra, K. Mapesa, N. Brancucci, Y. Antonova-Koch, K. Crouch, N. V. Simwela, J. Akinwale, D. Mitcheson, L. Solyakov, K. Dudek, C. Jones, , A. Tobin

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.

bioRxiv · Aug 31, 2018 · PreprintMicrobiology