Author

M. Prot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 9 Organism:human· 4 Organism:mouse· 3 Assay:proteomics· 3 Organism:virus· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

E. Simon-Loriere· 9 shared D. Planas· 6 shared H. Mouquet· 6 shared I. Staropoli· 6 shared O. Schwartz· 6 shared C. Planchais· 5 shared F. Guivel-Benhassine· 5 shared F. Porrot· 5 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersMicrobiology

E. Simon-Loriere

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

D. Planas, I. Staropoli, V. Michel, F. Lemoine, F. Donati, M. Prot, F. Porrot, F. G. Benhassine, B. Jeyarajah, A. Brisebarre, O. Dehan, L. Avon, W. Bolland, M. Hubert, J. Buchreiser, , O. Schwartz

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

W. Bolland, V. Michel, D. Planas, M. Hubert, F. Guivel-Benhassine, F. Porrot, I. Staropoli, M. N'Debi, C. Rodriguez, S. Fourati, M. Prot, C. Planchais, L. Hocqueloux, E. Simon-Loriere, H. Mouquet, , J. Buchrieser

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

bioRxiv · Sep 6, 2023Microbiology

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies

D. Planas, T. Bruel, I. Staropoli, F. Guivel-Benhassine, F. Porrot, P. Maes, L. Grzelak, M. Prot, S. Mougari, C. Planchais, J. Puech, M. Saliba, R. Sahraoui, F. Femy, N. Morel, , O. Schwartz

This study evaluates the neutralizing antibody resistance of SARS-CoV-2 Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to monoclonal antibodies and sera from vaccinated individuals.

bioRxiv · Nov 17, 2022Microbiology

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

N. Saunders, D. Planas, W. H. Bolland, C. Rodriguez, S. Fourati, J. Buchrieser, C. Planchais, M. Prot, I. Staropoli, F. Guivel-Benhassine, F. Porrot, D. Veyer, H. Pere, N. Robillard, M. Saliba, , O. Schwartz

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

bioRxiv · Jan 7, 2022Microbiology

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

X. Montagutelli, M. Prot, G. Jouvion, L. Levillayer, L. Conquet, E. Reyes-Gomez, F. Donati, M. Albert, S. van der Werf, J. Jaubert, E. Simon-Loriere

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

bioRxiv · Jul 10, 2021 · PreprintMicrobiology

Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals

D. Planas, D. Veyer, A. Baidaliuk, I. Staropoli, F. Guivel-Benhassine, M. Rajah, C. Planchais, F. Porrot, N. Robillard, J. Puech, M. Prot, F. Gallais, P. Gantner, A. Velay, J. Le Guen, , O. Schwartz

This study shows that the SARS-CoV-2 B.1.617.2 variant is less sensitive to monoclonal antibodies and sera from convalescent and vaccinated individuals compared to other variants.

bioRxiv · May 26, 2021 · PreprintMicrobiology

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

X. Montagutelli, M. Prot, L. Levillayer, E. Baquero Salazar, G. Jouvion, L. Conquet, M. Beretta, F. Donati, M. Albert, F. Gambaro, S. Behillil, V. Enouf, D. Rousset, J. Jaubert, S. van der Werf, , E. Simon-Loriere

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

bioRxiv · Mar 18, 2021 · PreprintMicrobiology

A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice

P. N. Frantz, A. Barinov, C. Ruffie, C. Combredet, V. Najburg, S. Teeravechyan, A. Jongkaewwattana, M. Prot, L. Conquet, X. Montagutelli, P. Fernandes, H. Strick-Marchand, J. Di Santo, E. Simon-Loriere, C. Gerke, F. Tangy

bioRxiv · Feb 17, 2021 · PreprintImmunology

Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

M. Plaze, D. Attali, M. Prot, A.-C. Petit, M. Blatzer, F. Vinckier, L. Levillayer, F. Perin-Dureau, A. Cachia, G. Friedlander, F. Chretien, E. Simon-Loriere, R. Gaillard

This study tests chlorpromazine's antiviral effect on SARS-CoV-2 in human and monkey cells, finding an IC50 of ~10M and suggesting its potential repurposing for COVID-19 treatment.

bioRxiv · May 5, 2020Microbiology