Author

M. Backovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Assay:cryo-EM· 1

Frequent Co-Authors

F. A. Rey· 5 shared I. Fernandez· 4 shared A. Gessain· 3 shared D. Brun· 3 shared F. Buseyne· 3 shared Y. Coquin· 3 shared A. Haouz· 2 shared F. Neipel· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersMicrobiology

F. A. Rey

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

I. Fernandez, F. Bontems, D. Brun, Y. Coquin, C. A. Goverde, B. E. Correia, A. Gessain, F. Buseyne, F. A. Rey, M. Backovic

The paper reports cryo-EM structures of foamy virus Env in pre- and post-fusion states, revealing structural similarity to paramyxovirus F proteins and suggesting an evolutionary link.

bioRxiv · Feb 9, 2024Microbiology

Tim-1 and Tim-4 mediate entry of the human Kaposi's sarcoma-associated herpesvirus and the related rhesus monkey rhadinovirus

S. Scribano, S. Schlagowski, S. Liu, T. Fricke, X. Yang, F. Neipel, A. K. Grosskopf, B. F. Hornich, M. Backovic, A. Ensser, A. S. Hahn

This paper identifies Tim-1 and Tim-4 as mediators of KSHV and RRV entry, showing their role in viral infection and highlighting their unique function compared to other herpesviruses.

bioRxiv · Oct 10, 2023 · PreprintMicrobiology

Neutralization of zoonotic retroviruses by human antibodies: genotype-specific epitopes within the receptor-binding domain from simian foamy virus

L. T. Dynesen, I. Fernandez, Y. Coquin, M. Delaplace, T. Montange, R. Njouom, C. Bilounga-Ndongo, F. A. Rey, A. Gessain, M. Backovic, F. Buseyne

This study identifies genotype-specific epitopes in the receptor-binding domain of simian foamy virus that are targeted by neutralizing antibodies, revealing mechanisms of immune evasion and neutralization.

bioRxiv · Nov 6, 2022Microbiology

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells

I. Fernandez, L. Tofdal Dynesen, Y. Coquin, R. Pederzoli, D. Brun, A. Haouz, A. Gessain, F. A. Rey, F. Buseyne, M. Backovic

The paper determines the X-ray structure of a simian Foamy Virus receptor binding domain, revealing its fold and key residues involved in heparan sulfate interaction.

bioRxiv · Oct 4, 2022Microbiology

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

T. L. Light, D. Brun, P. Guardado-Calvo, R. Pederzoli, A. Haouz, F. Neipel, F. A. Rey, K. Hristova, M. Backovic

This study identifies how HHV-8 uses molecular mimicry of ephrin ligands to bind EphA2, triggering signaling that facilitates viral entry and cytoskeleton remodeling.

bioRxiv · Mar 26, 2021Microbiology

Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus

S. Temmam, A. Barbarino, D. Maso, S. Behillil, V. Enouf, C. Huon, A. Jaraud, L. Chevallier, M. Backovic, P. Perot, P. Verwaerde, L. Tiret, S. van der Werf, M. Eloit

The paper tests domestic pets for SARS-CoV-2 infection after their owners were infected, finding no evidence of infection in the pets.

One Health · Dec 1, 2020Peer-reviewedMicrobiology