I. Fernandez

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

This paper investigates how VP3 protein of birnaviruses targets endosomal membranes via PI3P binding, revealing a two-stage mechanism critical for viral replication.

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

The paper reports cryo-EM structures of foamy virus Env in pre- and post-fusion states, revealing structural similarity to paramyxovirus F proteins and suggesting an evolutionary link.

A synthetic delivery vector for mucosal vaccination

This paper develops a synthetic delivery vector for mucosal vaccination that induces mucosal immunity and CD8+ T cell responses in mice.

Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals.

This study shows that Omicron BA.1 breakthrough infection in vaccinated individuals leads to long-term remodeling of memory B cells, enhancing neutralizing breadth and potency against common and BA.1 epitopes but not BA.5.

Neutralization of zoonotic retroviruses by human antibodies: genotype-specific epitopes within the receptor-binding domain from simian foamy virus

This study identifies genotype-specific epitopes in the receptor-binding domain of simian foamy virus that are targeted by neutralizing antibodies, revealing mechanisms of immune evasion and neutralization.

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells

The paper determines the X-ray structure of a simian Foamy Virus receptor binding domain, revealing its fold and key residues involved in heparan sulfate interaction.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

No priming, just fighting - endophytic yeast attenuates the defense response and the stress induced by Dutch elm disease in Ulmus minor

This study investigates how an endophytic yeast reduces the defense response and stress in elm trees infected with Dutch elm disease.

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

The paper assesses how well mRNA vaccine-induced memory B cells recognize the Omicron variant of SARS-CoV-2 and finds that Omicron evades recognition more than previous variants.

Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation

This study investigates the role of CYP1 family members and AhR in lung epithelial regulation of allergic airway inflammation, finding that CYP1B1 deficiency exacerbates inflammation.

Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals.

The study compares memory B cell responses in naive and recovered individuals after mRNA vaccination, showing enhanced expansion and neutralization against variants in recovered patients.

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.

This study tracks the maturation of SARS-CoV-2-specific memory B cells over 6 months, showing their persistence and mutation accumulation.

Large ribosomal subunit, eIF5B, Met-tRNAiMet and mRNA cooperate to complete accurate initiation.

The paper determines the cryoEM structure of a long-lived translation initiation intermediate involving eIF5B, Met-tRNAiMet, and the ribosome post GTP hydrolysis.

Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system

The paper determines the structure of a TniQ-Cascade complex using cryo-EM, revealing how it targets DNA and facilitates transposition by bacterial transposons.

A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.

The paper characterizes a novel viral IRES that assembles a functional 48S complex via an uAUG intermediate using cryo-EM and translation assays.

The Israeli Acute Paralysis Virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.

The paper characterizes the IAPV IRES structure using cryo-EM to show how it captures host ribosomes and redirects them to viral mRNA, providing insights for RNA-interference strategies against CCD.