PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix
E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan
This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.
bioRxiv · May 30, 2020 · PreprintCancer Biology