S. Dhayade

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

Impact of formate supplementation on body weight and plasma amino acids

This study examines the effects of sodium formate supplementation on body weight, plasma amino acids, and gut microbiota in mice, finding significant changes in females but not males.

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

This study identifies the MSP-RON axis as a driver of TNBC growth in a mouse model and shows that inhibiting RON reduces tumor progression.

Formate induces a metabolic switch in nucleotide and energy metabolism

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.