Author

D. Athineos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Blyth· 5 shared D. Sumpton· 3 shared S. Dhayade· 3 shared S. Lilla· 3 shared S. Zanivan· 3 shared E. J. Kay· 2 shared G. Koulouras· 2 shared J. Tait-Mulder· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

K. Blyth

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

C. I. Wittke, E. C. Cheung, D. Athineos, N. Clements, L. Butler, M. Hughes, V. Morrison, D. Watt, K. Blyth, K. Vousden, T. J. Humpton

This study shows that p53 and TIGAR protect against MASH by controlling redox balance, preventing ROS accumulation, fibrosis, and inflammation.

bioRxiv · May 20, 2024Cancer Biology

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

A. Santi, E. J. Kay, L. J. Neilson, L. McGarry, S. Lilla, M. Mullin, N. R. Paul, F. Fercoq, G. Koulouras, G. Rodriguez-Blanco, D. Athineos, S. Mason, M. Hughes, Y. Kieffer, C. Nixon, , S. Zanivan

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

bioRxiv · May 30, 2020 · PreprintCancer Biology

Impact of formate supplementation on body weight and plasma amino acids

S. Dhayade, M. Pietzke, R. Wiesheu, J. Tait-Mulder, D. Athineos, D. Sumpton, S. B. Coffelt, K. Blyth, A. B. Vazquez

This study examines the effects of sodium formate supplementation on body weight, plasma amino acids, and gut microbiota in mice, finding significant changes in females but not males.

bioRxiv · May 4, 2020Biochemistry

Formate induces a metabolic switch in nucleotide and energy metabolism

K. Oizel, J. Tait-Mulder, J. Fernandez-de-Cossio-Diaz, M. Pietzke, H. Brunton, S. Dhayade, D. Athineos, S. Lilla, G. Rodriguez Blanco, D. Sumpton, G. M. Mackay, K. Blyth, S. Zanivan, J. Meiser, A. Vazquez

This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.

bioRxiv · Aug 16, 2019Biochemistry