Author

E. Hamami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

R. R. Isberg· 4 shared W. Huo· 4 shared E. Geisinger· 3 shared I. Neisewander· 2 shared J. Hernandez-Bird· 2 shared T. van Opijnen· 2 shared A. Castaneda· 1 shared B. B. Aldridge· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

R. R. Isberg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

M. W. Tse, M. Zhu, B. Peters, E. Hamami, J. Chen, K. P. Davis, S. Nitz, J. Weller, T. Warrier, D. K. Hunt, Y. Morales, T. Kawate, J. L. Gaulin, J. H. Come, J. Hernandez-Bird, , P. C. Blainey

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

bioRxiv · Mar 26, 2024 · PreprintMicrobiology

Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumps

E. Hamami, W. Huo, K. Neal, I. Neisewander, S. Fnu, J. S. Freundlich, E. Geisinger, R. R. Isberg

The paper identifies essential genes in Acinetobacter baumannii that support efflux pump overproducer fitness during ciprofloxacin treatment, revealing roles in outer membrane integrity and pH homeostasis.

bioRxiv · Jan 4, 2024Microbiology

Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter baumannii

E. Hamami, W. Huo, A. Castaneda, J. Bai, S. Syal, J. C. Ortiz-Marquez, T. van Opijnen, E. Geisinger, R. R. Isberg

The paper identifies proteins essential for maintaining fitness in Acinetobacter baumannii strains overexpressing RND efflux pumps, highlighting the role of outer membrane integrity and compensatory mechanisms.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia

W. Huo, L. M. Busch, J. Hernandez-Bird, E. Hamami, C. W. Marshall, E. Geisinger, V. S. Cooper, T. van Opijnen, J. Rosch, R. R. Isberg

This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.

bioRxiv · Apr 7, 2021 · PreprintMicrobiology