MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.
M. Houlard, E. Cutts, M. S. Shamim…·K. Nasmyth
This paper shows MCPH1 inhibits condensin II during interphase by binding to NCAPG2, preventing chromosome condensation, and demonstrates that this regulation is essential for maintaining chromatin structure.