Author

E. Cutts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 4 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Vannini· 4 shared A. Musacchio· 2 shared D. Pan· 2 shared D. S. Rueda· 2 shared L. Aragon· 2 shared A. Borsellini· 1 shared A. Graziadei· 1 shared A. Mazouzi· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

A. Vannini

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Condensin II activation by M18BP1

A. Borsellini, D. Conti, E. Cutts, R. J. Harris, K. Walstein, A. Graziadei, V. Cecatiello, T. F. Aarts, R. Xie, A. Mazouzi, S. Sen, C. Hoencamp, R. Pleuger, S. Ghetti, L. Oberste-Lehn, , A. Vannini

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

bioRxiv · May 2, 2024Cell Biology

Substrate accessibility regulation of human TopIIa decatenation by cohesin

E. Cutts, S. Saravanan, G. Fisher, D. S. Rueda, L. Aragon

This study investigates how TOP2 resolves DNA braids and shows cohesin inhibits its activity by preventing substrate access.

bioRxiv · Nov 20, 2023Biophysics

Condensin compacts DNA in 15 nm steps and requires FACT for extrusion on chromatin

S. Sudhakar, G. L. Fisher, P. G. Escribano, J. G. Luis, E. Cutts, C. Cawood, L. Aragon, D. S. Rueda

The paper was withdrawn due to issues with two figures, and the authors do not wish it to be cited.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.

M. Houlard, E. Cutts, M. S. Shamim, J. Godwin, D. Weisz, A. Presser Aiden, E. Lieberman Aiden, L. Schermelleh, A. Vannini, K. Nasmyth

This paper shows MCPH1 inhibits condensin II during interphase by binding to NCAPG2, preventing chromosome condensation, and demonstrates that this regulation is essential for maintaining chromatin structure.

bioRxiv · Jul 20, 2021Cell Biology

Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

P. Choppakatla, B. Dekker, E. Cutts, A. Vannini, J. Dekker, H. Funabiki

This study shows H1.8 inhibits condensins and topo II to regulate chromosome length and individualization during mitosis.

bioRxiv · Dec 20, 2020Cell Biology

Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA

M. Kong, E. Cutts, D. Pan, F. Beuron, T. Kaliyappan, C. Xue, E. Morris, A. Musacchio, A. Vannini, E. Greene

This study shows human condensin I and II compact nucleosome-bound DNA through ATP-dependent motor activity, forming reversible DNA loops without displacing nucleosomes.

bioRxiv · Jun 27, 2019Biochemistry