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Primary ORCID profile (0000-0002-5086-6449 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
C. Steinek, M. Guirao Ortiz, G. Stumberger, A. J. Toelke, D. Hoerl, T. Carell, H. Harz, H. Leonhardt
This paper introduces a method to generate densely labeled oligonucleotides for detecting small genomic elements using FISH in single cells.
bioRxiv · Mar 15, 2024Cell Biology
M. K. Pabba, C. Ritter, V. O. Chagin, J. Meyer, K. Celikay, J. H. Stear, D. Loerke, K. Kolobynina, P. Prorok, A. K. Schmid, H. Leonhardt, K. Rohr, M. C. Cardoso
This study shows that replisome loading reduces chromatin motion during S-phase, independent of DNA synthesis activity.
eLife · Oct 31, 2023Peer-reviewedCell Biology
D. Weichenhan, A. Riedel, E. Sollier, U. H. Toprak, J. Hey, K. Breuer, J. A. Wierzbinska, A. Touzart, P. Lutsik, M. Baehr, A. Oestlund, C. Nilsson, S. Jacobsson, M. Edler, A. Waraky, , C. Plass
The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.
bioRxiv · Sep 13, 2023 · PreprintCancer Biology
S. Ullrich, S. Leidescher, Y. Feodorova, K. Thanisch, J.-B. Fini, B. Kaspers, F. Weber, B. Markova, D. Fuehrer, M. Romitti, S. Krebs, H. Blum, H. Leonhardt, S. Costagliola, H. Heuer, I. Solovei
The paper identifies thyroglobulin gene (Tg) as a permanently upregulated gene in thyrocytes across vertebrates, providing insights into mechanisms of sustained transcriptional activation.
bioRxiv · Jun 23, 2023Cell Biology
E. Ugur, A. de la Porte, S. Bultmann, M. Drukker, M. Mann, M. Wierer, H. Leonhardt
The paper develops a proteomic method to analyze chromatome dynamics during pluripotency phases, revealing regulatory complex binding and rearrangements.
bioRxiv · Aug 8, 2022 · PreprintBiochemistry
K. Hata, N. Kobayashi, K. Sugimura, W. Qin, D. Haxholli, Y. Chiba, S. Yoshimi, G. Hayashi, H. Onoda, T. Ikegami, C. B. Mulholland, A. Nishiyama, M. Nakanishi, H. Leonhardt, T. Konuma, K. Arita
This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.
bioRxiv · Jun 14, 2022Biochemistry
K. Brandstetter, T. Zuelske, T. Ragoczy, D. Hoerl, E. Haugen, E. Rynes, J. A. Stamatoyannopoulos, H. Leonhardt, G. Wedemann, H. Harz
The paper uses microscopy and modeling to study nanoscale chromatin organization in human cells, finding cell-to-cell differences in both active and inactive regions.
bioRxiv · May 27, 2021 · PreprintCell Biology
M. Cremer, K. Brandstetter, A. Maiser, S. S. Rao, V. Schmid, M. Guirao-Ortiz, N. Mitra, S. Mamberti, K. N. Klein, D. M. Gilbert, H. Leonhardt, M. C. Cardoso, E. Lieberman Aiden, H. Harz, T. Cremer
The paper shows cohesin-depleted cells undergo endomitosis and rebuild a multilobulated nucleus with functional compartments despite lacking cohesin.
bioRxiv · Sep 14, 2020Cell Biology
S. Leidescher, J. Ribisel, S. Ullrich, Y. Feodorova, E. Hildebrand, S. Bultmann, S. Link, K. Thanisch, C. B. Mulholland, J. Dekker, H. Leonhardt, L. Mirny, I. Solovei
This study investigates how transcription shapes genome spatial organization by analyzing long highly expressed genes and demonstrating the formation of transcription loops with polymerases and nascent RNAs.
bioRxiv · May 20, 2020Cell Biology
C. B. Mulholland, F. R. Traube, E. Parsa, E.-M. Eckl, M. Schoenung, M. Modic, M. D. Bartoschek, P. Stolz, J. Ryan, T. Carell, H. Leonhardt, S. Bultmann
The paper compares TET1 and TET2 contributions to cytosine oxidation during naive to primed pluripotency transition, finding distinct and differentiation-dependent roles in 5hmC and 5fC formation.
bioRxiv · Mar 13, 2018Cell Biology