Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
J. Fu, J. Li, C.-F. Li, C.-L. Tsai, W. Yin, J. Hou, P. Chen, Y. Cao, Y. Kang, Y. Sun, X. Xia, K. Furukawa, Y. Lu, M. Wu, Q. Huang, , P. Chiao
The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.
bioRxiv · Jul 28, 2022Cancer Biology