X. Xia

Exploring The Association of Student Perceptions of Their Teachers' Science Instruction and Emotional Engagement and The Variance between Grade Level

This study examines how student perceptions of science instruction relate to emotional engagement across grade levels, finding lower engagement and perception scores in higher grades.

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variants

This study shows that DNA aptamer nanomaterials can protect against diverse SARS-CoV-2 variants through respiratory mucosal administration, offering broad neutralization and superior protection compared to monoclonal antibodies.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer

This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

Genomic insights into photosymbiotic evolution in Tridacna squamosa

This study presents the first complete genome of Tridacna squamosa and integrates multi-omics data to uncover molecular mechanisms underlying photosymbiosis with dinoflagellates.

Rapid and Highly Sensitive Detection of Fentanyl and its Analogs by a Novel Chemiluminescence Immunoassay

This paper develops a chemiluminescence immunoassay for rapid, sensitive detection of fentanyl and its analogs in clinical and environmental samples with sub-picogram detection limits.

Use of Large Language Models to Aid Analysis of Textual Data

This paper explores using large language models to assist in deductive coding of qualitative research texts, comparing LLM outputs to human coders and discussing implications and limitations.

Consecutive treatments of methamphetamine promote the 4 development of cardiac pathological symptoms in zebrafish

This study investigates the effects of repeated methamphetamine exposure on zebrafish cardiac function, revealing decreased heart rate, increased heart rate variability, and fibrotic changes.

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

An autoactive NB-LRR gene causes Rht13 dwarfism in wheat

The paper identifies Rht13, an autoactive NB-LRR gene that causes dwarfism in wheat, offering a new approach for semidwarfing in crops.

Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo.

The paper shows urine-derived exosomes from IPF patients carry pro-fibrotic miRNAs that induce fibrosis in skin and lung models.

Comparative thermophysiology of marine Synechococcus CRD1 strains isolated from different thermal niches in iron-depleted areas

The paper compares thermophysiological traits of three CRD1 Synechococcus strains from different thermal niches, showing distinct thermotypes despite lacking typical cold thermotype features.

CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.

Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling

The paper identifies miR-306 and miR-79 as tumor-suppressor miRNAs that eliminate JNK-activated tumors in Drosophila by non-canonical activation of JNK signaling through targeting dRNF146.

Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane

The paper determines the structure of the ankyrin complex on human red blood cells and elucidates its assembly mechanism and role in mechanical stability.

FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

Cardiotoxic effects of methamphetamine associated with electrophysiological and epigenetic aberrations in Zebrafish

This study examines cardiotoxic effects of methamphetamine in zebrafish, finding increased heart rate but not QTc prolongation, along with myocardial damage and gene expression changes.

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

This paper develops a microelectrode array system for real-time ECG and EEG monitoring in Xenopus laevis under chemical exposure, demonstrating its ability to detect drug-induced physiological changes.

Structure-based screening of drug candidates targeting the SARS-CoV-2 envelope protein

This study identifies two E protein inhibitors for SARS-CoV-2 using structural modeling and virtual screening, including a compound in clinical trials.

A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

Pixelwise H-score: a novel digital image analysis based-metric to quantify membrane biomarker expression from immunohistochemistry images

This paper introduces a new digital image analysis metric, the pixelwise H-score, to quantify membrane biomarker expression in IHC images, showing it is comparable or better than existing methods.

Response of methanogen community to elevation of cathode potentials in the presence of magnetite

This study shows that magnetite enables methanogens to adapt to higher cathode potentials in electrochemical reactors, enhancing electromethanogenesis.

Nav1.3 and fibroblast growth factor homologous factor 14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells

This study identifies Nav1.3 and FGF14 as key determinants of TTX-sensitive sodium current properties in mouse adrenal chromaffin cells.

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice

This study shows that LRRC26-associated BK channels in goblet cells protect mice from colitis by regulating potassium flux and MUC2 secretion.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.