Author

J. B. Fleming

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2

Frequent Co-Authors

Y. Kang· 3 shared A. F. Tassielli· 2 shared B. Sarcar· 2 shared F. Beato· 2 shared H. Wang· 2 shared J. Yao· 2 shared J. Zhao· 2 shared K. Jiang· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

Y. Kang

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6 papers

Recent·Most cited

The translational role of SOS1 in colorectal cancer

D. Alem, X. Yang, F. Beato, B. Sarcar, A. F. Tassielli, R. Dai, T. L. Hogenson, M. A. Park, K. Jiang, J. Cai, Y. Yuan, M. E. Fernandez-Zapico, A. C. Tan, J. B. Fleming, H. Xie

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

J. Fu, J. Li, C.-F. Li, C.-L. Tsai, W. Yin, J. Hou, P. Chen, Y. Cao, Y. Kang, Y. Sun, X. Xia, K. Furukawa, Y. Lu, M. Wu, Q. Huang, , P. Chiao

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

bioRxiv · Jul 28, 2022Cancer Biology

RBFOX2 deregulation promotes pancreatic cancer metastasis through alternative splicing

M. Maurin, M. Ranjouri, K. Martin, R. Miner, J. Y. Newberg, D. Du, B. Centeno, J. B. Fleming, X. B. Yu, E. Guccione, M. Black, K. M. Mann

This study identifies RBFOX2 deregulation as a driver of pancreatic cancer metastasis through alternative splicing of ABI1, enhancing cancer cell stemness and invasiveness.

bioRxiv · Jun 1, 2022Cancer Biology

Establishing a Living Biobank of Patient-Derived Organoids of Intraductal Papillary Mucinous Neoplasms of the Pancreas

F. Beato, D. Reveron, K. B. Dezsi, A. Ortiz, J. O. Johnson, D.-T. Chen, K. Ali, S. J. Yoder, D. Jeong, M. Malafa, P. Hodul, K. Jiang, B. A. Centeno, M. A. Abdalah, J. A. Balasi, , J. B. Fleming

This study establishes a living biobank of patient-derived organoids from intraductal papillary mucinous neoplasms to study their progression and identify biomarkers for early detection and prevention.

Laboratory Investigation · Feb 1, 2021Peer-reviewedCancer Biology

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

J. Deng, Y. Kang, C.-C. Cheng, X. Li, B. Dai, M. H. Katz, T. Men, M. P. Kim, E. Koay, H. Huang, R. A. Brekken, J. B. Fleming

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

bioRxiv · Aug 5, 2020Cancer Biology

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

B. Tu, J. Yao, S. Ferri-Borgogno, J. Zhao, S. Chen, Q. Wang, L. Yan, X. Zhou, C. Zhu, S. Bang, Q. Chang, C. A. Bristow, Y. Kang, H. Zheng, H. Wang, , H. Ying

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

bioRxiv · Aug 17, 2019Cancer Biology