K. Furukawa

This study investigates how hydrostatic pressure activates Ras in vitro and shows that GAP and GEF domains enhance this activation.

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

The paper identifies AP2A1 upregulation in senescent human fibroblasts, which strengthens focal adhesions via integrin β1 translocation along stress fibers, maintaining large cell size.

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

The paper develops a mathematical model to explain how fibroblast migration velocity depends on substrate stiffness through changes in stress fiber maturation and contractile force.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.