E. Mane

Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence

This study identifies aberrant cytoplasmic MLH1 localization in sub-clonal breast cancer cells as a driver of endocrine resistance, showing it predicts response to CDK4/6 inhibitors.

Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

This paper develops a multimodal transformer model using H&E images and text reports to predict recurrence scores in hormone receptor-positive breast cancer, achieving high accuracy and generalizability.

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.