M. Ivanova

Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence

This study identifies aberrant cytoplasmic MLH1 localization in sub-clonal breast cancer cells as a driver of endocrine resistance, showing it predicts response to CDK4/6 inhibitors.

Large-scale phenotypic and genomic characterization of Listeria monocytogenes susceptibility to quaternary ammonium compounds

This study characterizes QAC susceptibility in 1,671 L. monocytogenes isolates, identifies genetic markers linked to tolerance, and examines global prevalence across 37,897 genomes.

The pore conformation of lymphocyte perforin

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.

Conformational Tuning of Amylin by Charged Styrene-maleic-acid Copolymers

This study shows that charged styrene-maleic-acid copolymers alter amylin aggregation and conformation, with SMAQA inhibiting fibrillation and SMAEA accelerating it.

High Throughput Screening at the Membrane Interface Reveals New Inhibitors of Amyloid-β

This study identifies 5 small molecules that inhibit amyloid-β aggregation at the cell-membrane interface, which is relevant for Alzheimer's disease.

Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

This study uses PMA-nanodiscs to study Aβ1-40 aggregation, showing they trap intermediates and reduce neurotoxicity of oligomers.

Zinc Boosts EGCG’s hIAPP Amyloid Inhibition Both in Solution and Membrane

This study shows that zinc enhances EGCG's ability to inhibit hIAPP amyloid aggregation both in solution and in the presence of lipid membranes.