A. Marra

Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

This paper develops a multimodal transformer model using H&E images and text reports to predict recurrence scores in hormone receptor-positive breast cancer, achieving high accuracy and generalizability.

Prolonged XPO1 inhibition is essential for optimal anti-leukemic activity in NPM1-mutated AML

This study shows that prolonged XPO1 inhibition is more effective than intermittent dosing in NPM1-mutated AML by achieving stable HOX downregulation and anti-leukemic activity.

Drosophila antimicrobial peptides and lysozymes regulate gut microbiota composition and abundance

This study shows that antimicrobial peptides and lysozymes in Drosophila regulate gut microbiota composition and abundance, with their effects exacerbated during aging.

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

The paper reports changes in Drosophila hemolymph proteome upon infection with Spiroplasma poulsonii, revealing chronic Toll pathway activation and candidate proteins controlling bacterial growth.

The metalloproteinase inhibitor Prinomastat reduces AML growth,prevents stem cell loss and improves chemotherapy effectiveness

This study shows that prinomastat, an MMP inhibitor, reduces AML growth, prevents stem cell loss, and enhances chemotherapy effectiveness in a mouse model.

The Drosophila Baramicin polypeptide gene protects against fungal infection

This study identifies a novel Drosophila antifungal peptide gene, Baramicin A, showing its role in antifungal resistance and immune response.

Macrophage Function is Regulated by NPM1-Mediated 2'-O-Methylation

This study shows that NPM1 regulates macrophage function through rRNA 2'-O-methylation and translation control, revealing a role in immune cell activity.