Mechanism and site of action of big dynorphin on ASIC1a
C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedstroem, E. P. Bennett, T. Lynagh, K. Stromgaard, J. Andersen, S. Pless
This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.
Proceedings of the National Academy of Sciences · Mar 12, 2020Peer-reviewedBiophysics