DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
C. K. Rezi, M. Aslanyan, G. D. Diwan, T. Cheng, M. Chamlali, K. Junger, Z. Anvarian, e. lorentzen, K. B. Pauly, Y. Bahadori, E. F. Fernandes, F. Qian, S. Tosi, S. T. Christensen, S. F. Pedersen, , L. B. Pedersen
This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.
bioRxiv · Nov 10, 2023Cell Biology