J.-L. Casanova

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

The paper identifies a monocyte/dendritic cell gene signature in severe MIS-C with myocarditis, linked to NF-κB activity and cytokine signaling.

SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4

This study shows SARS-CoV-2 activates human plasmacytoid pre-dendritic cells (pDC) via UNC93B and IRAK4, leading to interferon and cytokine production.

Distinct antibody repertoires against endemic human coronaviruses in children and adults

The paper analyzes antibody repertoires against endemic human coronaviruses in children and adults, finding distinct epitope targets and cross-reactivity patterns.

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy

The paper identifies a homozygous STAT2 mutation causing type I interferonopathy by disrupting USP18 interaction and signal termination.

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

The paper reports a rare POLR3F mutation in monozygotic twins with severe CNS VZV vasculitis, linking RNA polymerase III dysfunction to increased susceptibility to VZV infection.

IRF4 haploinsufficiency in a family with Whipples disease

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.